On one hand, diterpenes cafestol and kahweol present in unfiltered coffee and caffeine each appear to increase risk of coronary heart disease. High quality studies have confirmed the cholesterol-raising effect of diterpenes. Coffee consumption is also associated with an increase of plasma homocysteine, a risk factor for coronary heart disease.
On the other hand, a lower risk of heart disease among moderate coffee drinkers might be due to antioxidants found in coffee.besides that, caffeine can increase the risk of heart attack, especially among those people who carry the "slow" gene variant for the enzyme that metabolizes caffeine.
